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Monday, July 27, 2020 | History

2 edition of Aggregation of human blood platelets by immune complexes in the sedimentation pattern test found in the catalog.

Aggregation of human blood platelets by immune complexes in the sedimentation pattern test

Gunnar MyllylaМ€

Aggregation of human blood platelets by immune complexes in the sedimentation pattern test

by Gunnar MyllylaМ€

  • 216 Want to read
  • 33 Currently reading

Published by Munksgaard in Copenhagen .
Written in English

    Subjects:
  • Blood -- Sedimentation.,
  • Blood cells.,
  • Blood platelet aggregation.,
  • Immunology -- Technique.

  • Edition Notes

    At head of title: From the Department of Virology, University of Helsinki, and the Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.

    StatementGunnar Myllylä.
    SeriesScandinavian journal of haematology., 19
    Classifications
    LC ClassificationsQR187.S4 M94
    The Physical Object
    Pagination56 p. :
    Number of Pages56
    ID Numbers
    Open LibraryOL5240548M
    LC Control Number75311831

    Jewell DP, MacLennan IC. Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol. Jun; 14 (2)– Myllylä G. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Scand J Haematol Suppl. ; – Platelet, colourless, nonnucleated blood component that is important in the formation of blood clots (coagulation). Platelets are found only in the blood of mammals. Platelets are formed when cytoplasmic fragments of megakaryocytes, which are very large cells in the bone marrow, pinch off into the.

    Contrary to the serum IgG complexes, they often yield precipitation with isolated Clq (i)- With the platelet aggregation test elaborated by Penttinen et al. (11, 12) it is possible to detect circulating soluble immune complexes. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Tbromb. Diatbes. Haemorrb. lung infection. The demonstration of antigen (Stuttg.) 20, , reacting in vitro with specific antibodies in the Myllyla, G.: Aggregation of human blood platelets by patient sera, resulting in immune compleximmune complexes in the sedimentation pattern test. Scand. J. Haematol.

      Myllylä G. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Scand J Haematol Suppl. ; – [Google Scholar] Penttinen K, Vaheri A, Myllylä G. Detection and characterization of immune complexes by the platelet aggregation test. I. Complexes formed in vitro. Clin Exp Immunol. Isolation of human platelets from whole blood This protocol describes the isolation of human platelets from whole blood. To prevent the activation of platelets during the procedure, strong mechanical forces (e.g. fast pipetting, vigorous shaking) should be avoided. In addition, the platelet inhibitors indicated in the protocol can be used.


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Aggregation of human blood platelets by immune complexes in the sedimentation pattern test by Gunnar MyllylaМ€ Download PDF EPUB FB2

Get this from a library. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

[Gunnar Myllylä]. Scand J Haematol Suppl. ; Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Myllylä by: Corpus ID: Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

@article{MyllylAggregationOH, title={Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.}, author={Gunnar Myllyl{\"a}}, journal={Scandinavian journal of haematology.

Macanovic M, Lachmann PJ. Conglutinin binding polyethylene glycol precipitation assay for immune complexes. Clin Exp Immunol. Nov; 38 (2)– [PMC free article] Myllylä G. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

Scand J Haematol Suppl. ; –Cited by: Myllylä G. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

Scand J Haematol Suppl. ; – Penttinen K, Vaheri A, Myllylä G. Detection and characterization of immune complexes by the platelet aggregation test. Complexes formed in vitro. Clin Exp Immunol.

Mar; 8 (3)–Cited by: Myllylä G. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Scand J Haematol Suppl. ; – Hallberg T. In vitro cytotoxicity of human lymphocytes for sensitized chicken erythrocytes is inhibited by sera from rheumatoid arthritis patients.

Scand J Immunol. ; 1 (4)– Micromethods for laboratory investigations are advantageous because only small amounts of reagents are necessary, thus making larger experiments possible. This paper describes a micromethod for platelet aggregation, based on the sedimentation pattern of cells.

The platelets were suspended in phosphate-buffered sodium chloride solution free of calcium or magnesium. A rapid test for detection of circulating immune complexes in a small serum sample was developed to facilitate clinical diagnosis of immune complex disorders.

The test is based on a selective precipitation of soluble circulating complexes of antigen-antibody in % concentration of high-molecular polyethylene glycol. The plates were stored in a refrigerator (4°C) for 16 to 20 hours and subsequently the sedimentation pattern of the platelets was evaluated.

A smooth white button indicated a negative result. Various ring formations (+ or ++) or an even pattern on the bottom of. Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients.

Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythrocyte sedimentation rates or rheumatoid factor titers.

Detection and characterization of immune complexes by the platelet aggregation test. Circulating complexes. Clin. Exp. Immunol., 8, PubMed Google Scholar. Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

Scand. Haematol. G. MyllylüAggregation of human blood platelets by immune complexes in the sedimentation pattern test Scand J Haematol, 19 (suppl) (), pp. l Google Scholar. The ciq binding test for the detection of soluble immune complexes.

In: B.R. Bloom and J.R. David: In vitro methods in cell-mediated and tumor immunity. Academic Press, New York, p.Immune reactions of human blood platelets. A comparative study on the effects on platelets of heterologous antiplatet antiserum, antigen-antibody complexes, aggregated gammaglobulin and thrombin.

Thromb Diath Haemorrh. Nov 15; 20 (1)– Myllylä G. Role of platelets in immune-complex-induced aggregation of human blood platelets. Myllyla G () Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

Scand J Haematol [Suppl] 19 Myllyla G, Vaheri A, Penttinen K () Detection and characterization of immune complexes by the platelet aggregation test. Circulating complexes. Clin Exp Immunol 8: – Google Scholar. INTRODUCTION In Penttinen and Myllyla introduced the sedimentation pattern test to detect platelet aggregation caused by IgG-immune complexes.

While these authors were interested in the measurement of circulating immune complexes and of specific post infection anti-viral antibodies (Myllyla et al.,; Paluoso et al., The platelet aggregating activity found in patients with HLA-B27 and associated rheumatic and cardiac conditions may reflect serum factors that increase the stickiness of platelets and increase.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proceedings of the National Academy of Sciences. Platelets have significant role in modulating clot formation.

Additionally, emerging data indicates that platelets have considerable roles in inflammation and immune response. Platelets gather at the damaged cite and adhere to white blood cells.

Subsequently, they release cytokines and chemokines which are chemotactic for neutrophils and monocytes. Platelet aggregation is a crucial step in the process of clot formation, which stops bleeding.

A platelet aggregation test can be performed to determine how well platelets are sticking together. The test measures this by using a platelet antagonist to initiate clumping in the patient's blood. Aggregation of human platelets (Pl.A) induced by IgG immune complexes of rabbit Ea-aEa, NIP() BSA-aNIP) and human (tetanus toxoid aT) origin and by heat aggregated human polyclonal IgG was.Myllylä G () Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

() The C1q binding test for soluble immune complexes: Clinical correlations obtained in patients with cancer. J Natl Cancer Inst Google Scholar.

G. Holmlund, Tissue Typing Laboratory, Finnish Red Cross Blood Service, Kivihaantie 7, SP Helsi Finland Transfusion Several reports state that in the platelet aggregation test for immune complexes platelets are aggregated also by antibodies directed against platelet surface antigens (3, 5).